Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease.
Minter MR, Zhang C, Leone V, Ringus DL, Zhang X, Oyler-Castrillo P, Musch MW, Liao F, Ward JF, Holtzman DM, Chang EB, Tanzi RE, Sisodia SS. Sci Rep. 2016. doi: 10.1038/srep30028.
COMMENT: Alzheimer disease cognitive decline correlates mainly with neuroinflamation and microgliosis. It has been described how gut microbiome influences brain function in part modulating host innate immunity. + info
Brito IL, Yilmaz S, Huang K, Xu L, Jupiter SD, Jenkins AP, Naisilisili W, Tamminen M, Smillie CS, Wortman JR, Birren BW, Xavier RJ, Blainey PC, Singh AK, Gevers D, Alm EJ. Nature. Jul 2016.
COMMENT: The microbiome is many times analyzed as a static picture but we could have more valuable information if we study it as a dynamic thing in a similar way that meteorological changes or the dynamic movements of persons travelling. + info
Bacterial Diversity and Community Structure of Supragingival Plaques in Adults with Dental Health or Caries Revealed by 16S Pyrosequencing.
Xiao C, Ran S, Huang Z, Liang J. Front Microbiol. 2016. doi: 10.3389/fmicb.2016.01145.
COMMENT: The authors analyze microbiome composition of dental plaque in health and caries disease by means of 454 technology sequencing 16S rRNA.They find a core plaque microbiome which is more diverse in health than in the caries samples,... + info
Vernocchi P, Del Chierico F, Putignani L. Front Microbiol. 2016. doi: 10.3389/fmicb.2016.01144.
COMMENT: The microbiome analysis involves not only metagenomics but also metatranscriptomics, metaproteomics and metabolomics. + info