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August 2016

Uncovering Earth's virome.
18/09/2016
Publication

Uncovering Earth's virome.

Paez-Espino D, Eloe-Fadrosh EA, Pavlopoulos GA, Thomas AD, Huntemann M, Mikhailova N, Rubin E, Ivanova NN, Kyrpides NC.  Nature. Aug 2016.

COMMENT: Analyzing bacteria in microbiomes is much more easier than analyzing viruses. 16S approach for bacterial and archaeal taxonomic profiling is a convenient general approach. For viruses we don't have a similar strategy and shotgun... + info

Host Physiologic Changes Induced by Influenza A Virus Lead to Staphylococcus aureus Biofilm Dispersion and Transition from Asymptomatic Colonization to Invasive Disease.
21/08/2016
Publication

Host Physiologic Changes Induced by Influenza A Virus Lead to Staphylococcus aureus Biofilm Dispersion and Transition from Asymptomatic Colonization to Invasive Disease.

Reddinger RM, Luke-Marshall NR, Hakansson AP, Campagnari AA.  MBio. 2016. doi: 10.1128/mBio.01235-16e01235-16.

COMMENT: It is well known that after influenza virus infection Staphylococcus aureus can change from asymptomatic colonization to produce an invasive staphylococcal disease being one of the most important cause of secondary pn... + info

A subpopulation of high IL-21-producing CD4(+) T cells in Peyer's Patches is induced by the microbiota and regulates germinal centers.
21/08/2016
Publication

A subpopulation of high IL-21-producing CD4(+) T cells in Peyer's Patches is induced by the microbiota and regulates germinal centers.

Jones L, Ho WQ, Ying S, Ramakrishna L, Srinivasan KG, Yurieva M, Ng WP, Subramaniam S, Hamadee NH, Joseph S, Dolpady J, Atarashi K, Honda K, Zolezzi F, Poidinger M, Lafaille JJ, Curotto de Lafaille MA.  Sci Rep. 2016. doi: 10.1038/srep30784.

COMMENT: T follicular helper (Tfh) cells are crucial to the development of T cell-dependent antibody responses and produce IL-21 which is important for B cell responses.  IL-21 also promotes the production of IgA in the gut. In... + info

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