Chemopreventive Metabolites Are Correlated with a Change in Intestinal Microbiota Measured in A-T Mice and Decreased Carcinogenesis.
Cheema AK, Maier I, Dowdy T, Wang Y, Singh R, Ruegger PM, Borneman J, Fornace AJ, Schiestl RH. PLoS One. 2016. doi: 10.1371/journal.pone.0151190.
COMMENT: Ataxia telangiectasia (A-T) is a recessive genetic disorder of childhood that occurs 1/1000,000 individuals. Mutations in ATM gene are involved in A-T pathogenesis and there is a Atm-deficient mouse as model of the disease.... + info
Zitvogel L, Ayyoub M, Routy B, Kroemer G. Cell. Apr 2016. doi: 10.1016/j.cell.2016.03.001S0092-8674(16)30256-2.
A comprenhensive review article focused on the relation between the microbiome and the anticancer immune response. The article mainly describes two putative mechanism of action: - The presence of certain bacteria reshapes Tcell repertoire enabling... + info