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April 2016

Chemopreventive Metabolites Are Correlated with a Change in Intestinal Microbiota Measured in A-T Mice and Decreased Carcinogenesis.
27/08/2016
Publication

Chemopreventive Metabolites Are Correlated with a Change in Intestinal Microbiota Measured in A-T Mice and Decreased Carcinogenesis.

Cheema AK, Maier I, Dowdy T, Wang Y, Singh R, Ruegger PM, Borneman J, Fornace AJ, Schiestl RH.  PLoS One. 2016. doi: 10.1371/journal.pone.0151190.

COMMENT: Ataxia telangiectasia (A-T) is a recessive genetic disorder of childhood that occurs 1/1000,000 individuals. Mutations in ATM gene are involved in A-T pathogenesis and there is a Atm-deficient mouse as model of the disease.... + info

Microbiome and Anticancer Immunosurveillance
26/08/2016
Publication

Microbiome and Anticancer Immunosurveillance

Zitvogel L, Ayyoub M, Routy B, Kroemer G.  Cell. Apr 2016. doi: 10.1016/j.cell.2016.03.001S0092-8674(16)30256-2.

A comprenhensive review article focused on the relation between the microbiome and the anticancer immune response. The article mainly describes two putative mechanism of action:  - The presence of certain bacteria reshapes Tcell repertoire enabling... + info

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