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March 2019

Variations in early gut microbiome are associated with childhood eczema.
20/03/2019
Publication

Variations in early gut microbiome are associated with childhood eczema.

Zhang Y, Jin S, Wang J, Zhang L, Mu Y, Huang K, Zhao B, Zhang K, Cui Y, Li S.  FEMS Microbiol Lett. Mar 2019.

COMMENT: Gut microbiota plays an important role in human immunological processes, potentially affecting allergic diseases such as eczema. Eczema is the most common chronic inflammatory skin disorder in children and one of the strongest... + info

Fecal and blood microbiota profiles and presence of nonalcoholic fatty liver disease in obese versus lean subjects.
20/03/2019
Publication

Fecal and blood microbiota profiles and presence of nonalcoholic fatty liver disease in obese versus lean subjects.

Yun Y, Kim HN, Lee EJ, Ryu S, Chang Y, Shin H, Kim HL, Kim TH, Yoo K, Kim HY.  PLoS One. 2019. doi: 10.1371/journal.pone.0213692.

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver diseases. In this work, the authors investigate the association between fecal and blood microbiome profiles in people obese versus lean with or without NAFLD, sequencing... + info

19/03/2019
Publication

Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic.

Tomkovich S, Dejea CM, Winglee K, Drewes JL, Chung L, Housseau F, Pope JL, Gauthier J, Sun X, Mühlbauer M, Liu X, Fathi P, Anders RA, Besharati S, Perez-Chanona E, Yang Y, Ding H, Wu X, Wu S, White JR, Gharaibeh RZ, Fodor AA, Wang H, Pardoll DM, Jobin C, Sears CL.  J Clin Invest. Mar 2019. doi: 10.1172/JCI124196124196.

COMMENT: This study reveals that homogenates of biofilm-positive colon mucosa from patients with colorectal cancer and healthy subjects promote tumor development in colorectal cancer mouse models. + info

Relationship between vitamin D status and the vaginal microbiome during pregnancy.
18/03/2019
Publication

Relationship between vitamin D status and the vaginal microbiome during pregnancy.

Jefferson KK, Parikh HI, Garcia EM, Edwards DJ, Serrano MG, Hewison M, Shary JR, Powell AM, Hollis BW, Fettweis JM, Strauss Iii JF, Buck GA, Wagner CL.  J Perinatol. Mar 2019. doi: 10.1038/s41372-019-0343-8.

COMMENT: The authors investigate if plasma 25(OH)D concentrations are associated with the vaginal microbiome. They analyze vaginal 16S rRNA gene taxonomic profiles and plasma 25-hydroxyvitamin D [25(OH)D]... + info

Oral Nickel Changes of Intestinal Microflora in Mice.
14/03/2019
Publication

Oral Nickel Changes of Intestinal Microflora in Mice.

Zhou X, Li J, Sun JL.  Curr Microbiol. Mar 2019. doi: 10.1007/s00284-019-01664-1.

COMMENT: In this work, the authors investigate the effect of oral nickel administration on intestinal microbiome in mice to support some preliminary studies that link the dietary nickel with modifications in the gut microflora.  + info

The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy.
05/03/2019
Publication

The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy.

Havel JJ, Chowell D, Chan TA.  Nat Rev Cancer. Mar 2019. doi: 10.1038/s41568-019-0116-x.

Anticancer immunotherapy treatments based on checkpoint inhibitors (ICI) are getting more and more important. For example, antibodies targeting the proteins PD1-PDL1 have been aproved by the FDA as first or second-line treatments for several kinds... + info

The gut microbiota and blood pressure in experimental models.
04/03/2019
Publication

The gut microbiota and blood pressure in experimental models.

Jama HA, Kaye DM, Marques FZ.  Curr Opin Nephrol Hypertens. Mar 2019. doi: 10.1097/MNH.0000000000000476.

COMMENT: This work reviews the evidence that support the relationship between gut microbiota and the development and maintenance of hypertension in experimental models. + info

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