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February 2019

Dopamine Is a Siderophore-Like Iron Chelator That Promotes Salmonella enterica Serovar Typhimurium Virulence in Mice.
16/02/2019
Publication

Dopamine Is a Siderophore-Like Iron Chelator That Promotes Salmonella enterica Serovar Typhimurium Virulence in Mice.

Dichtl S, Demetz E, Haschka D, Tymoszuk P, Petzer V, Nairz M, Seifert M, Hoffmann A, Brigo N, Würzner R, Theurl I, Karlinsey JE, Fang FC, Weiss G.  MBio. Feb 2019.

COMMENT: This work can have an important impact in septic shock produced by Salmonella since it reports that dopamine, used in septic shock treatment, promotes Salmonella virulence because acts as siderophore-like iron chelator that stimulates bacterial... + info

The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice
15/02/2019
Publication

The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice

Zheng P et al. Science Advances. Vol. 5, no. 2, eaau8317.

COMMENT: This work analyzes possible relationships between the gut microbiome from patients with schizophrenia (SCZ) and the schizophrenic... + info

A human gut bacterial genome and culture collection for improved metagenomic analyses.
13/02/2019
Publication

A human gut bacterial genome and culture collection for improved metagenomic analyses.

Forster SC, Kumar N, Anonye BO, Almeida A, Viciani E, Stares MD, Dunn M, Mkandawire TT, Zhu A, Shao Y, Pike LJ, Louie T, Browne HP, Mitchell AL, Neville BA, Finn RD, Lawley TD.  Nat Biotechnol. Feb 2019. doi: 10.1038/s41587-018-0009-7.

COMMENT: The authors present the Human Gastrointestinal Bacteria Culture Collection (HBC). A collection of 737 bacterial genomes from 273 species from human gastrointestinal microbiome and the corresponding isolates. Both the sequence data and the... + info

1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
13/02/2019
Publication

1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.

Zou Y, Xue W, Luo G, Deng Z, Qin P, Guo R, Sun H, Xia Y, Liang S, Dai Y, Wan D, Jiang R, Su L, Feng Q, Jie Z, Guo T, Xia Z, Liu C, Yu J, Lin Y, Tang S, Huo G, Xu X, Hou Y, Liu X, Wang J, Yang H, Kristiansen K, Li J, Jia H, Xiao L.  Nat Biotechnol. Feb 2019. doi: 10.1038/s41587-018-0008-8.

COMMENT: 1,520 draft reference genomes of culturable bacteria from human gut microbiomes from healthy donors. + info

Periodontitis and mechanisms of cardiometabolic risk: Novel insights and future perspectives.
11/02/2019
Publication

Periodontitis and mechanisms of cardiometabolic risk: Novel insights and future perspectives.

Mesa F, Magan-Fernandez A, Castellino G, Chianetta R, Nibali L, Rizzo M.  Biochim Biophys Acta Mol Basis Dis. Feb 2019.

COMMENT: The authors in this review article summarize the current knowledge of the influence of the periodontitis in the development of the cardiovascular disease. They review recent epidemiological studies that support the association of the periodontitis... + info

The neuroactive potential of the human gut microbiota in quality of life and depression.
09/02/2019
Publication

The neuroactive potential of the human gut microbiota in quality of life and depression.

Valles-Colomer M, Falony G, Darzi Y, Tigchelaar EF, Wang J, Tito RY, Schiweck C, Kurilshikov A, Joossens M, Wijmenga C, Claes S, Van Oudenhove L, Zhernakova A, Vieira-Silva S, Raes J.  Nat Microbiol. Feb 2019. doi: 10.1038/s41564-018-0337-x.

COMMENT: This work is focused to the neuroactive potential of the human gut microbiome and is centered in studying how microbiome features correlate with host quality of life and depression. The findings of this work add new support for the importance... + info

Microbiome as a therapeutic target in alcohol-related liver disease.
23/01/2019
Publication

Microbiome as a therapeutic target in alcohol-related liver disease.

Sarin SK, Pande A, Schnabl B.  J Hepatol. Feb 2019.

COMMENT:  Modulation of gut microbial composition by faecal microbiota transplantation or precision microbiome therapies are the new therapeutic options which are currently being evaluated for patients with alcohol-related liver disease. + info

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