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August 2019


 

Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes.
27/09/2019
Publication

Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes.

Riquelme E, Zhang Y, Zhang L, Montiel M, Zoltan M, Dong W, Quesada P, Sahin I, Chandra V, San Lucas A, Scheet P, Xu H, Hanash SM, Feng L, Burks JK, Do KA, Peterson CB, Nejman D, Tzeng CD, Kim MP, Sears CL, Ajami N, Petrosino J, Wood LD, Maitra A, Straussman R, Katz M, White JR, Jenq R, Wargo J, McAllister F.  Cell. Aug 2019.

COMMENT: This work was developed to investigate the role of the tumor microbiome and the immune system in long-term survival pancreatic adenocarcinoma (PDAC) patients. This interesting study was done using 16S rRNA gene sequencing of... + info

MicroPro: using metagenomic unmapped reads to provide insights into human microbiota and disease associations.
26/09/2019
Publication

MicroPro: using metagenomic unmapped reads to provide insights into human microbiota and disease associations.

Zhu Z, Ren J, Michail S, Sun F.  Genome Biol. 08 2019. doi: 10.1186/s13059-019-1773-5.

COMMENT: This publication describes a data analysis pipeline called MicroPro to analyze metagenomics data especially focused on unknown microorganisms that could be the origin of the unmapped reads. The pipeline analyzes all reads, the mapped... + info

Gut Microbiota and Colonization Resistance against Bacterial Enteric Infection.
23/08/2019
Publication

Gut Microbiota and Colonization Resistance against Bacterial Enteric Infection.

Ducarmon QR, Zwittink RD, Hornung BVH, van Schaik W, Young VB, Kuijper EJ.  Microbiol Mol Biol Rev. Aug 2019.

COMMENT: This review summarizes current knowledge on colonization resistance to pathogens mediated by the gut microbiome. + info

Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus
22/08/2019
Publication

Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus

Sohn G. Kim et al..  Nature. 21 August 2019.

COMMENT: This work demonstrates how lantibiotics produced by some commensal bacteria are able to inhibit the colonization of the gut by pathogens as important as the vancomycin-resistant Enterococcus faecium (VRE), a leading cause of hospital-acquired... + info

The gastrointestinal fate of limonin and its effect on gut microbiota in mice.
21/08/2019
Publication

The gastrointestinal fate of limonin and its effect on gut microbiota in mice.

Gu M, Sun J, Qi C, Cai X, Goulette T, Song M, You X, Sela DA, Xiao H.  Food Funct. Aug 2019. doi: 10.1039/c9fo01274e.

COMMENT: In this work the authors study the effect of Limonin, widely found in citrus fruits, in the mice microbiome. Mice were fed with a diet containing 0.05% limonin for 9 weeks. Using liquid chromatography-mass spectrum analysis they... + info

Large-Scale Analyses of Human Microbiomes Reveal Thousands of Small, Novel Genes.
21/08/2019
Publication

Large-Scale Analyses of Human Microbiomes Reveal Thousands of Small, Novel Genes.

Sberro H, Fremin BJ, Zlitni S, Edfors F, Greenfield N, Snyder MP, Pavlopoulos GA, Kyrpides NC, Bhatt AS.  Cell. Aug 2019.

COMMENT: This work is oriented to the detection and study of small proteins in human Microbiomes.  The authors carried out a comparative genomics analysis on 1,773 human-associated metagenomes from four different body sites:  •  ... + info

Urinary microbiota - a potential biomarker and therapeutic target for bladder cancer.
19/08/2019
Publication

Urinary microbiota - a potential biomarker and therapeutic target for bladder cancer.

Bi H, Tian Y, Song C, Li J, Liu T, Chen Z, Chen C, Huang Y, Zhang Y.  J Med Microbiol. Aug 2019. doi: 10.1099/jmm.0.001058.

COMMENT: In this study 29 bladder cancer patients and 26 non-cancer patients were collected prior to antibiotic administration to analyze their urinary microbiota. The authors detected some differences that suggest that urine microbiome... + info

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