Allaire JM, Crowley SM, Law HT, Chang SY, Ko HJ, Vallance BA. Trends Immunol. Sep 2018.
COMMENT: The intestinal mucosa, a single layer of cells, interacts with and, at the same time, is a barrier to luminal microbiota. The communication between microbes and intestinal epithelial cells (IECs) and how these cells interacts with... + info
Evaluation of gastric microbiome and metagenomic function in patients with intestinal metaplasia using 16S rRNA gene sequencing.
Park CH, Lee AR, Lee YR, Eun CS, Lee SK, Han DS. Helicobacter. Feb 2019. doi: 10.1111/hel.12547.
COMMENT: In this study the authors try to find the influence of the gastric microbiome in the development of gastric cancers independently of Helicobacter pylori. To do so they analyze the gastric microbiome by means of 16S sequencing analysis in... + info
Critical steps in clinical shotgun metagenomics for the concomitant detection and typing of microbial pathogens.
Couto N, Schuele L, Raangs EC, Machado MP, Mendes CI, Jesus TF, Chlebowicz M, Rosema S, Ramirez M, Carriço JA, Autenrieth IB, Friedrich AW, Peter S, Rossen JW. Sci Rep. Sep 2018. doi: 10.1038/s41598-018-31873-w.
COMMENT: Shotgun metagenomics can help in the identification and typing of microbial pathogens directly from patient samples added or instead of to the classical microbial cultured used routinely in clinical microbiology. Shotgun metagenomics is... + info
Ren R, Wang Z, Sun H, Gao X, Sun G, Peng L, Yan B, Yang Y. Sci Rep. Sep 2018. doi: 10.1038/s41598-018-31738-2.
COMMENT: In this study the authors analyze the gastric microbiota in patients with gastric polyposis and compare it to the microbiota from healthy controls. Based on the results obtained they construct a microbial dysbiosis index (MDI) able to distinguish... + info
Maternal gut and breast milk microbiota affect infant gut antibiotic resistome and mobile genetic elements.
Pärnänen K, Karkman A, Hultman J, Lyra C, Bengtsson-Palme J, Larsson DGJ, Rautava S, Isolauri E, Salminen S, Kumar H, Satokari R, Virta M. Nat Commun. 09 2018. doi: 10.1038/s41467-018-06393-w.
COMMENT: The authors analyze the potential source of antibiotics resistance genes and mobile genetic elements in infant gut. Mainly during the first 6 months of life. + info
Pan-genomic analyses identify key Helicobacter pylori pathogenic loci modified by carcinogenic host microenvironments.
Noto JM, Chopra A, Loh JT, Romero-Gallo J, Piazuelo MB, Watson M, Leary S, Beckett AC, Wilson KT, Cover TL, Mallal S, Israel DA, Peek RM. Gut. 10 2018. doi: 10.1136/gutjnl-2017-313863.
COMMENT: Helicobacter pylori is the strongest risk factor for gastric cancer but the pathogenesis appears to depend on bacterial and microenvironmental factors. In this study two carcinogenic microenvironmental factors of the host, iron... + info