Distinct microbes, metabolites, and ecologies define the microbiome in deficient and proficient mismatch repair colorectal cancers.
Hale VL, Jeraldo P, Chen J, Mundy M, Yao J, Priya S, Keeney G, Lyke K, Ridlon J, White BA, French AJ, Thibodeau SN, Diener C, Resendis-Antonio O, Gransee J, Dutta T, Petterson XM, Sung J, Blekhman R, Boardman L, Larson D, Nelson H, Chia N. Genome Med. Oct 2018. doi: 10.1186/s13073-018-0586-6.
COMMENT: Several studies have analyzed the differences in the microbial communities from colorectal cancers (CRC) and proved the importance of the microbiome in the CRC pathogenesis and prognosis. Up to date, the main factors found to have an... + info
Puente-Sánchez F, Arce-Rodríguez A, Oggerin M, García-Villadangos M, Moreno-Paz M, Blanco Y, Rodríguez N, Bird L, Lincoln SA, Tornos F, Prieto-Ballesteros O, Freeman KH, Pieper DH, Timmis KN, Amils R, Parro V. Proc Natl Acad Sci U S A. Oct 2018. doi: 10.1073/pnas.1808176115.
COMMENT: In this work, after analyzing samples from the Iberian Pyrite Belt Mars analog (southwestern Spain), the authors present molecular, microscopic, and metagenomic evidences that support the cyanobacterial predominance in deep... + info
Clostridioides difficile uses amino acids associated with gut microbial dysbiosis in a subset of patients with diarrhea.
Battaglioli EJ, Hale VL, Chen J, Jeraldo P, Ruiz-Mojica C, Schmidt BA, Rekdal VM, Till LM, Huq L, Smits SA, Moor WJ, Jones-Hall Y, Smyrk T, Khanna S, Pardi DS, Grover M, Patel R, Chia N, Nelson H, Sonnenburg JL, Farrugia G, Kashyap PC. Sci Transl Med. Oct 2018.
COMMENT: In this work the authors propose a new prophylactic dietary intervention for Clostridioides difficile infections (CDI) based on the proline auxothrophy that this opportunistic pathogen has. Using human fecal transplantation into germ-free... + info
Stewart CJ, Ajami NJ, O'Brien JL, Hutchinson DS, Smith DP, Wong MC, Ross MC, Lloyd RE, Doddapaneni H, Metcalf GA, Muzny D, Gibbs RA, Vatanen T, Huttenhower C, Xavier RJ, Rewers M, Hagopian W, Toppari J, Ziegler AG, She JX, Akolkar B, Lernmark A, Hyoty H, Vehik K, Krischer JP, Petrosino JF. Nature. Oct 2018. doi: 10.1038/s41586-018-0617-x.
COMMENT: This work is oriented to the characterization of the microbiome in early life in a large, multi-centre population as as part of the TEDDY (The Environmental Determinants of Diabetes in the Young) study (https://teddy.epi.usf.edu/TEDDY/). 12,500... + info