Kwak MJ, Kong HG, Choi K, Kwon SK, Song JY, Lee J, Lee PA, Choi SY, Seo M, Lee HJ, Jung EJ, Park H, Roy N, Kim H, Lee MM, Rubin EM, Lee SW, Kim JF. Nat Biotechnol. Oct 2018. doi: 10.1038/nbt.4232.
COMMENT: In this interesting work, the authors use the tomato plant and bacterial wilt as a model system to examine how the root microbiome contributes to disease resistance. + info
Endospores and other lysis-resistant bacteria comprise a widely shared core community within the human microbiota.
Kearney SM, Gibbons SM, Poyet M, Gurry T, Bullock K, Allegretti JR, Clish CB, Alm EJ. ISME J. Oct 2018. doi: 10.1038/s41396-018-0192-z.
COMMENT: This paper implements a resistant cell fraction enrichment protocol from human fecal samples and 16S rDNA sequencing to investigate the presence of bacteria with resistant states in the mammalian gut environment and whether these resistant... + info
Jarvis KG, Daquigan N, White JR, Morin PM, Howard LM, Manetas JE, Ottesen A, Ramachandran P, Grim CJ. Front Microbiol. 2018. doi: 10.3389/fmicb.2018.02540.
COMMENT: Detection of foodborne pathogens is frequently hampered by the indigenous microbiota of the food. Characterizing baseline microbiomes in foods is important for the implementation of microbiome profiling methods for detecting pathogens in... + info
Moeller AH, Suzuki TA, Phifer-Rixey M, Nachman MW. Science. 10 2018. doi: 10.1126/science.aat7164.
COMMENT: This paper describes a long-term and multigenerational assay to investigate the routes by which specific bacterial lineages within the microbiota are transmitted between hosts in a murine model. The authors derived 17 inbred mouse lines from... + info
Towards an Individualized Nutrition Treatment: Role of the Gastrointestinal Microbiome in the Interplay Between Diet and Obesity.
Adalsteinsdottir SA, Magnusdottir OK, Halldorsson TI, Birgisdottir BE. Curr Obes Rep. Dec 2018. doi: 10.1007/s13679-018-0321-z.
COMMENT: This review is focused on the relationship between microbiome and obesity. The review includes new evidences about the influence of microbiome on energy metabolism and studies about communication between host and gastrointestinal... + info
Duerkop BA. PLoS Pathog. 10 2018. doi: 10.1371/journal.ppat.1007310.
COMMENT: This work is a review centred on the bacterial phages. The review also analyzes the applicability of knowledge about phages in Biomedicine mainly as therapeutic agents for modulating human microbiome bacterial communities and as disease... + info
Distinct microbes, metabolites, and ecologies define the microbiome in deficient and proficient mismatch repair colorectal cancers.
Hale VL, Jeraldo P, Chen J, Mundy M, Yao J, Priya S, Keeney G, Lyke K, Ridlon J, White BA, French AJ, Thibodeau SN, Diener C, Resendis-Antonio O, Gransee J, Dutta T, Petterson XM, Sung J, Blekhman R, Boardman L, Larson D, Nelson H, Chia N. Genome Med. Oct 2018. doi: 10.1186/s13073-018-0586-6.
COMMENT: Several studies have analyzed the differences in the microbial communities from colorectal cancers (CRC) and proved the importance of the microbiome in the CRC pathogenesis and prognosis. Up to date, the main factors found to have an... + info
Puente-Sánchez F, Arce-Rodríguez A, Oggerin M, García-Villadangos M, Moreno-Paz M, Blanco Y, Rodríguez N, Bird L, Lincoln SA, Tornos F, Prieto-Ballesteros O, Freeman KH, Pieper DH, Timmis KN, Amils R, Parro V. Proc Natl Acad Sci U S A. Oct 2018. doi: 10.1073/pnas.1808176115.
COMMENT: In this work, after analyzing samples from the Iberian Pyrite Belt Mars analog (southwestern Spain), the authors present molecular, microscopic, and metagenomic evidences that support the cyanobacterial predominance in deep... + info
Clostridioides difficile uses amino acids associated with gut microbial dysbiosis in a subset of patients with diarrhea.
Battaglioli EJ, Hale VL, Chen J, Jeraldo P, Ruiz-Mojica C, Schmidt BA, Rekdal VM, Till LM, Huq L, Smits SA, Moor WJ, Jones-Hall Y, Smyrk T, Khanna S, Pardi DS, Grover M, Patel R, Chia N, Nelson H, Sonnenburg JL, Farrugia G, Kashyap PC. Sci Transl Med. Oct 2018.
COMMENT: In this work the authors propose a new prophylactic dietary intervention for Clostridioides difficile infections (CDI) based on the proline auxothrophy that this opportunistic pathogen has. Using human fecal transplantation into germ-free... + info
Stewart CJ, Ajami NJ, O'Brien JL, Hutchinson DS, Smith DP, Wong MC, Ross MC, Lloyd RE, Doddapaneni H, Metcalf GA, Muzny D, Gibbs RA, Vatanen T, Huttenhower C, Xavier RJ, Rewers M, Hagopian W, Toppari J, Ziegler AG, She JX, Akolkar B, Lernmark A, Hyoty H, Vehik K, Krischer JP, Petrosino JF. Nature. Oct 2018. doi: 10.1038/s41586-018-0617-x.
COMMENT: This work is oriented to the characterization of the microbiome in early life in a large, multi-centre population as as part of the TEDDY (The Environmental Determinants of Diabetes in the Young) study (https://teddy.epi.usf.edu/TEDDY/). 12,500... + info