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November 2018

Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota.
15/02/2019
Publication

Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota.

Teng Y, Ren Y, Sayed M, Hu X, Lei C, Kumar A, Hutchins E, Mu J, Deng Z, Luo C, Sundaram K, Sriwastva MK, Zhang L, Hsieh M, Reiman R, Haribabu B, Yan J, Jala VR, Miller DM, Van Keuren-Jensen K, Merchant ML, McClain CJ, Park JW, Egilmez NK, Zhang HG.  Cell Host Microbe. Nov 2018.

COMMENT: It is known that diet can alter the gut microbiota. For that, it could be used to mitigate disease. In this study, the authors proposes a mechanism which could ameliorate mouse colitis (induced by dextran sulfate sodium (DSS)). + info

The gut microbiota at the intersection of diet and human health.
11/02/2019
Publication

The gut microbiota at the intersection of diet and human health.

Gentile CL, Weir TL.  Science. Nov 2018. doi: 10.1126/science.aau5812.

COMMENT: There is a mutualistic relation between gut microbiome and diet. Diet affects the gut microbiome and bacteria from the microbiome participate in the digestion and absorption of nutrients from the diet affecting human health and phisiology.... + info

Current progress and future opportunities in applications of bioinformatics for biodefense and pathogen detection: report from the Winter Mid-Atlantic Microbiome Meet-up, College Park, MD, January 10, 2018.
07/02/2019
Publication

Current progress and future opportunities in applications of bioinformatics for biodefense and pathogen detection: report from the Winter Mid-Atlantic Microbiome Meet-up, College Park, MD, January 10, 2018.

Meisel JS, Nasko DJ, Brubach B, Cepeda-Espinoza V, Chopyk J, Corrada-Bravo H, Fedarko M, Ghurye J, Javkar K, Olson ND, Shah N, Allard SM, Bazinet AL, Bergman NH, Brown A, Caporaso JG, Conlan S, DiRuggiero J, Forry SP, Hasan NA, Kralj J, Luethy PM, Milton DK, Ondov BD, Preheim S, Ratnayake S, Rogers SM, Rosovitz MJ, Sakowski EG, Schliebs NO, Sommer DD, Ternus KL, Uritskiy G, Zhang SX, Pop M, Treangen TJ.  Microbiome. Nov 2018. doi: 10.1186/s40168-018-0582-5.

COMMENT: In January of 2018, The Mid-Atlantic Microbiome Meet-up had their fourth meeting. The meeting was about recent advances in biodefense, focused on infectious disease and metagenomic methods for pathogen detection. + info

Diagnostic Potential and Interactive Dynamics of the Colorectal Cancer Virome.
04/02/2019
Publication

Diagnostic Potential and Interactive Dynamics of the Colorectal Cancer Virome.

Hannigan GD, Duhaime MB, Ruffin MT, Koumpouras CC, Schloss PD.  MBio. Nov 2018.

COMMENT: The authors analyze by means of shotgun metagenomics the gut virome associated to colorectal patients and highlight the role bacteriophages may have in the tumor development + info

Microbiome dynamics in obesity.
01/02/2019
Publication

Microbiome dynamics in obesity.

Thaiss CA.  Science. Nov 2018. doi: 10.1126/science.aav6870.

COMMENT: An interesting article about temporal and spatial dynamics of the intestinal microbiome in obesity and about how it influences central features of metabolic disease. The authors highligh 3 main points that could explain this impact of... + info

Defining cooperative roles for colonic microbiota and Muc2 mucin in mediating innate host defense against Entamoeba histolytica.
29/01/2019
Publication

Defining cooperative roles for colonic microbiota and Muc2 mucin in mediating innate host defense against Entamoeba histolytica.

Leon-Coria A, Kumar M, Moreau F, Chadee K.  PLoS Pathog. 11 2018. doi: 10.1371/journal.ppat.1007466.

Comment: Recent studies have linked microbiota with the outcome of Entamoeba histolytica (Eh) infection, however the relationship is poorly understood. MUC2 is the major secretory mucin in the gastrointestinal tract, it has previously found that Eh... + info

Colonocyte metabolism shapes the gut microbiota.
23/01/2019
Publication

Colonocyte metabolism shapes the gut microbiota.

Litvak Y, Byndloss MX, Bäumler AJ.  Science. Nov 2018.

COMMENT: The gut microbiota affects human health, but we are only just beginning to develop a mechanistic understanding of some of the host-microbe interactions involved. Litvak et al. review how host colon epithelial cells mediate the ... + info

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