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May 2018

The role of the microbiome for human health: from basic science to clinical applications.
24/05/2018
Publication

The role of the microbiome for human health: from basic science to clinical applications.

Mohajeri MH, Brummer RJM, Rastall RA, Weersma RK, Harmsen HJM, Faas M, Eggersdorfer M.  Eur J Nutr. May 2018. doi: 10.1007/s00394-018-1703-4.

COMMENT: The role of the human gut microbiota in health and disease is beginning to be understood. + info

Intracellular replication of Streptococcus pneumoniae inside splenic macrophages serves as a reservoir for septicaemia.
23/05/2018
Publication

Intracellular replication of Streptococcus pneumoniae inside splenic macrophages serves as a reservoir for septicaemia.

Ercoli G, Fernandes VE, Chung WY, Wanford JJ, Thomson S, Bayliss CD, Straatman K, Crocker PR, Dennison A, Martinez-Pomares L, Andrew PW, Moxon ER, Oggioni MR.  Nat Microbiol. May 2018. doi: 10.1038/s41564-018-0147-1.

COMMENT:  This is a very interesting study analysing how intracellular Streptococcus pneumoniae dividing inside CD169+ splenic macrophages are the origin of intravenous induced Sepsis in mice: + info

Gut microbiota utilize immunoglobulin A for mucosal colonization.
23/05/2018
Publication

Gut microbiota utilize immunoglobulin A for mucosal colonization.

Donaldson GP, Ladinsky MS, Yu KB, Sanders JG, Yoo BB, Chou WC, Conner ME, Earl AM, Knight R, Bjorkman PJ, Mazmanian SK.  Science. 05 2018. doi: 10.1126/science.aaq0926.

COMMENT: Experiments in mice suggest that Bacteroides fragilis change its surface to faciliate the binding of IgA. It facilitates adherence to gut mucosa in vivo. The authors propose that IgA mediated responses are involved in the stablishment... + info

Early Salmonella Typhimurium infection in pigs disrupts Microbiome composition and functionality principally at the ileum mucosa.
22/05/2018
Publication

Early Salmonella Typhimurium infection in pigs disrupts Microbiome composition and functionality principally at the ileum mucosa.

Argüello H, Estellé J, Zaldívar-López S, Jiménez-Marín Á, Carvajal A, López-Bascón MA, Crispie F, O'Sullivan O, Cotter PD, Priego-Capote F, Morera L, Garrido JJ.  Sci Rep. May 2018. doi: 10.1038/s41598-018-26083-3.

COMMENT: Salmonella is a major foodborne pathogen with a significant number of cases and outbreaks every year. Poultry meat, eggs and pork are the main sources of human salmonellosis. The host microbiota may play a role in resistance to, and... + info

Diversity and antimicrobial potential in sea anemone and holothurian microbiomes.
16/05/2018
Publication

Diversity and antimicrobial potential in sea anemone and holothurian microbiomes.

León-Palmero E, Joglar V, Álvarez PA, Martín-Platero A, Llamas I, Reche I.  PLoS One. 2018. doi: 10.1371/journal.pone.0196178.

COMMENT: Microbial pathogens, including bacteria and fungi, are responsible for multiple diseases. These infections affect not only humans but also crops, livestock, and aquaculture generating the need of new antimicrobial agents, in part, due... + info

Development of the Human Mycobiome over the First Month of Life and across Body Sites.
06/05/2018
Publication

Development of the Human Mycobiome over the First Month of Life and across Body Sites.

Ward TL, Dominguez-Bello MG, Heisel T, Al-Ghalith G, Knights D, Gale CA.  mSystems..

COMMENT: Early-life microbial colonization plays an important role in the healthy development of an infant. Extensive epidemiological surveys of the human microbiome have improved our understanding of how factors such as birth mode, diet, and... + info

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