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March 2018

The human skin microbiome.
28/05/2018
Publication

The human skin microbiome.

Byrd AL, Belkaid Y, Segre JA.  Nat Rev Microbiol. Mar 2018. doi: 10.1038/nrmicro.2017.157.

COMMENT: Our skin is home to millions of bacteria, fungi and viruses that compose the skin microbiota. Skin acts as a physical barrier to prevent the invasion of foreign pathogens while providing a home to the commensal microbiota. Despite this, the... + info

Commensal Microbes Induce Serum IgA Responses that Protect against Polymicrobial Sepsis.
23/05/2018
Publication

Commensal Microbes Induce Serum IgA Responses that Protect against Polymicrobial Sepsis.

Wilmore JR, Gaudette BT, Gomez Atria D, Hashemi T, Jones DD, Gardner CA, Cole SD, Misic AM, Beiting DP, Allman D.  Cell Host Microbe. Mar 2018.

COMMENT: In this interesting paper the authors investigate the relationship between the gut microbiome in mice and the presence and levels of IgA in blood and plasma cell in Bone Marrow. + info

Extensive impact of non-antibiotic drugs on human gut bacteria.
21/05/2018
Publication

Extensive impact of non-antibiotic drugs on human gut bacteria.

Maier L, Pruteanu M, Kuhn M, Zeller G, Telzerow A, Anderson EE, Brochado AR, Fernandez KC, Dose H, Mori H, Patil KR, Bork P, Typas A.  Nature. Mar 2018. doi: 10.1038/nature25979.

COMMENT: It is known that taking antibiotics can disrupt our gut microbiome and result in unintended consequences for health and disease. This study reveals that many non-antibiotic drugs might also alter the composition of our gut bacteria... + info

Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection.
29/04/2018
Publication

Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection.

Thaiss CA, Levy M, Grosheva I, Zheng D, Soffer E, Blacher E, Braverman S, Tengeler AC, Barak O, Elazar M, Ben-Zeev R, Lehavi-Regev D, Katz MN, Pevsner-Fischer M, Gertler A, Halpern Z, Harmelin A, Aamar S, Serradas P, Grosfeld A, Shapiro H, Geiger B, Elinav E.  Science. 03 2018. doi: 10.1126/science.aar3318.

COMMENT: In this work the authors discover a conection between hyperglycemia and systemic inflammation that involves microbial translocation trough altered intestinal barrier. + info

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes.
01/04/2018
Publication

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes.

Zhao L, Zhang F, Ding X, Wu G, Lam YY, Wang X, Fu H, Xue X, Lu C, Ma J, Yu L, Xu C, Ren Z, Xu Y, Xu S, Shen H, Zhu X, Shi Y, Shen Q, Dong W, Liu R, Ling Y, Zeng Y, Wang X, Zhang Q, Wang J, Wang L, Wu Y, Zeng B, Wei H, Zhang M, Peng Y, Zhang C.  Science. Mar 2018. doi: 10.1126/science.aao5774.

COMMENT: This publication in Science is centered around the benefits that the short-chain fatty acid (SCFA), produced by some gut commensal bacteria, exercise over Type 2 Diabetes  Mellitus (T2DM) patients. In a randomized clinical... + info

Interrelation of Diet, Gut Microbiome, and Autoantibody Production.
25/03/2018
Publication

Interrelation of Diet, Gut Microbiome, and Autoantibody Production.

Petta I, Fraussen J, Somers V, Kleinewietfeld M.  Front Immunol. 2018. doi: 10.3389/fimmu.2018.00439.

COMMENT: Increasing evidence is being gathered for the interplay between diet, microbiome, and autoantibody production. B cells possess a predominant role in adaptive immune responses via antibody -dependent and -independent functions. The microbiome... + info

Metatranscriptome of the Oral Microbiome in Health and Disease.
18/03/2018
Publication

Metatranscriptome of the Oral Microbiome in Health and Disease.

Solbiati J, Frias-Lopez J.  J Dent Res. Mar 2018. doi: 10.1177/0022034518761644.

COMMENT: Imbalance in the composition of the microbiome, also referred to as microbial dysbiosis, is directly linked to developing certain conditions. Dysbiosis of the oral microbiome is a prime example of how this imbalance leads to disease in the... + info

The Soil-Borne Legacy.
11/03/2018
Publication

The Soil-Borne Legacy.

Bakker PAHM, Pieterse CMJ, de Jonge R, Berendsen RL.  Cell. Mar 2018.

COMMENT: Exciting developments in high-throughput molecular analyses of the plant microbiome pinpointed enhanced nutrient uptake, improvement of root architecture, and protection of the host against biotic and abiotic stress as key functions of the... + info

Environment dominates over host genetics in shaping human gut microbiota.
06/03/2018
Publication

Environment dominates over host genetics in shaping human gut microbiota.

Rothschild D, Weissbrod O, Barkan E, Kurilshikov A, Korem T, Zeevi D, Costea PI, Godneva A, Kalka IN, Bar N, Shilo S, Lador D, Vila AV, Zmora N, Pevsner-Fischer M, Israeli D, Kosower N, Malka G, Wolf BC, Avnit-Sagi T, Lotan-Pompan M, Weinberger A, Halpern Z, Carmi S, Fu J, Wijmenga C, Zhernakova A, Elinav E, Segal E.  Nature. Feb 2018. doi: 10.1038/nature25973.

COMMENT:  This study has found that our microbiome affects nearly every aspect of our health and its microbial composition, which varies from individual to individual, may hold the key to everything from weight gain to moods. While some microbiome... + info

CD1d-mediated lipid presentation by CD11c+cells regulates intestinal homeostasis.
06/03/2018
Publication

CD1d-mediated lipid presentation by CD11c+cells regulates intestinal homeostasis.

Sáez de Guinoa J, Jimeno R, Gaya M, Kipling D, Garzón MJ, Dunn-Walters D, Ubeda C, Barral P.  EMBO J. Mar 2018.

COMMENT: The composition of the intestinal microbiota varies significantly between individuals, and evidence suggests that alterations in the populations of commensal bacteria (dysbiosis) can result in susceptibility to multiple pathological conditions... + info

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