Byrd AL, Belkaid Y, Segre JA. Nat Rev Microbiol. Mar 2018. doi: 10.1038/nrmicro.2017.157.
COMMENT: Our skin is home to millions of bacteria, fungi and viruses that compose the skin microbiota. Skin acts as a physical barrier to prevent the invasion of foreign pathogens while providing a home to the commensal microbiota. Despite this, the... + info
Wilmore JR, Gaudette BT, Gomez Atria D, Hashemi T, Jones DD, Gardner CA, Cole SD, Misic AM, Beiting DP, Allman D. Cell Host Microbe. Mar 2018.
COMMENT: In this interesting paper the authors investigate the relationship between the gut microbiome in mice and the presence and levels of IgA in blood and plasma cell in Bone Marrow. + info
Maier L, Pruteanu M, Kuhn M, Zeller G, Telzerow A, Anderson EE, Brochado AR, Fernandez KC, Dose H, Mori H, Patil KR, Bork P, Typas A. Nature. Mar 2018. doi: 10.1038/nature25979.
COMMENT: It is known that taking antibiotics can disrupt our gut microbiome and result in unintended consequences for health and disease. This study reveals that many non-antibiotic drugs might also alter the composition of our gut bacteria... + info
Thaiss CA, Levy M, Grosheva I, Zheng D, Soffer E, Blacher E, Braverman S, Tengeler AC, Barak O, Elazar M, Ben-Zeev R, Lehavi-Regev D, Katz MN, Pevsner-Fischer M, Gertler A, Halpern Z, Harmelin A, Aamar S, Serradas P, Grosfeld A, Shapiro H, Geiger B, Elinav E. Science. 03 2018. doi: 10.1126/science.aar3318.
COMMENT: In this work the authors discover a conection between hyperglycemia and systemic inflammation that involves microbial translocation trough altered intestinal barrier. + info
Zhao L, Zhang F, Ding X, Wu G, Lam YY, Wang X, Fu H, Xue X, Lu C, Ma J, Yu L, Xu C, Ren Z, Xu Y, Xu S, Shen H, Zhu X, Shi Y, Shen Q, Dong W, Liu R, Ling Y, Zeng Y, Wang X, Zhang Q, Wang J, Wang L, Wu Y, Zeng B, Wei H, Zhang M, Peng Y, Zhang C. Science. Mar 2018. doi: 10.1126/science.aao5774.
COMMENT: This publication in Science is centered around the benefits that the short-chain fatty acid (SCFA), produced by some gut commensal bacteria, exercise over Type 2 Diabetes Mellitus (T2DM) patients. In a randomized clinical... + info
Petta I, Fraussen J, Somers V, Kleinewietfeld M. Front Immunol. 2018. doi: 10.3389/fimmu.2018.00439.
COMMENT: Increasing evidence is being gathered for the interplay between diet, microbiome, and autoantibody production. B cells possess a predominant role in adaptive immune responses via antibody -dependent and -independent functions. The microbiome... + info
Solbiati J, Frias-Lopez J. J Dent Res. Mar 2018. doi: 10.1177/0022034518761644.
COMMENT: Imbalance in the composition of the microbiome, also referred to as microbial dysbiosis, is directly linked to developing certain conditions. Dysbiosis of the oral microbiome is a prime example of how this imbalance leads to disease in the... + info
Bakker PAHM, Pieterse CMJ, de Jonge R, Berendsen RL. Cell. Mar 2018.
COMMENT: Exciting developments in high-throughput molecular analyses of the plant microbiome pinpointed enhanced nutrient uptake, improvement of root architecture, and protection of the host against biotic and abiotic stress as key functions of the... + info
Rothschild D, Weissbrod O, Barkan E, Kurilshikov A, Korem T, Zeevi D, Costea PI, Godneva A, Kalka IN, Bar N, Shilo S, Lador D, Vila AV, Zmora N, Pevsner-Fischer M, Israeli D, Kosower N, Malka G, Wolf BC, Avnit-Sagi T, Lotan-Pompan M, Weinberger A, Halpern Z, Carmi S, Fu J, Wijmenga C, Zhernakova A, Elinav E, Segal E. Nature. Feb 2018. doi: 10.1038/nature25973.
COMMENT: This study has found that our microbiome affects nearly every aspect of our health and its microbial composition, which varies from individual to individual, may hold the key to everything from weight gain to moods. While some microbiome... + info
Sáez de Guinoa J, Jimeno R, Gaya M, Kipling D, Garzón MJ, Dunn-Walters D, Ubeda C, Barral P. EMBO J. Mar 2018.
COMMENT: The composition of the intestinal microbiota varies significantly between individuals, and evidence suggests that alterations in the populations of commensal bacteria (dysbiosis) can result in susceptibility to multiple pathological conditions... + info