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June 2018

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.
24/08/2018
Publication

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.

Olson CA, Vuong HE, Yano JM, Liang QY, Nusbaum DJ, Hsiao EY.  Cell. Jun 2018.

COMMENT: This work describes the experiments that support the idea that the previously reported beneficial effects of a ketogenic diet on epileptic seizures are mediated by changes in enzymatic activities from gut microbiome. The metabolic impact... + info

Probiotic strains detect and suppress cholera in mice.
01/07/2018
Publication

Probiotic strains detect and suppress cholera in mice.

Mao N, Cubillos-Ruiz A, Cameron DE, Collins JJ.  Sci Transl Med. Jun 2018.

COMMENT: This is a very imaginative work in which the authors use Lactococcus lactis bacteria for cholera detection and treatment. They use natural Lactococcus lactis (present in cheese and butter) to inhibit Vibrio cholera via lactic... + info

A taxonomic signature of obesity in a large study of American adults.
29/06/2018
Publication

A taxonomic signature of obesity in a large study of American adults.

Peters BA, Shapiro JA, Church TR, Miller G, Trinh-Shevrin C, Yuen E, Friedlander C, Hayes RB, Ahn J.  Sci Rep. Jun 2018. doi: 10.1038/s41598-018-28126-1.

COMMENT:  The microbiome is an enticing candidate to target for obesity prevention and treatment. Experiments in germ-free mice colonized with gut microbiota from wild-type mice, obese mice, or obese humans, demonstrate that microbiota play a... + info

Inter-population variation in the Atlantic salmon microbiome reflects environmental and genetic diversity.
25/06/2018
Publication

Inter-population variation in the Atlantic salmon microbiome reflects environmental and genetic diversity.

Uren Webster TM, Consuegra S, Hitchings M, Garcia de Leaniz C.  Appl Environ Microbiol. Jun 2018.

COMMENT: The microbiome has a crucial influence on host phenotype, and is of broad interest to ecological and evolutionary research. Yet, the extent of variation that occurs in the microbiome within and between populations is unclear. + info

Absolute quantitation of microbiota abundance in environmental samples.
22/06/2018
Publication

Absolute quantitation of microbiota abundance in environmental samples.

Tkacz A, Hortala M, Poole PS.  Microbiome. Jun 2018. doi: 10.1186/s40168-018-0491-7.

COMMENT: The environmental microbial community has multiple components that are normally abundant and are typically investigated by PCR amplification of marker genes. However, for most studies, only one microbiota domain, such as bacteria, is investigated.... + info

The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease.
15/06/2018
Publication

The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease.

Makki K, Deehan EC, Walter J, Bäckhed F.  Cell Host Microbe. Jun 2018.

COMMENT: Diet is not only essential to maintain human growth, reproduction, and health, but it also modulates and supports the symbiotic microbial communities that colonize the digestive tract-the gut microbiota. Type, quality, and origin of our food... + info

Gut dysbiosis: a potential link between increased cancer risk in ageing and inflammaging.
13/06/2018
Publication

Gut dysbiosis: a potential link between increased cancer risk in ageing and inflammaging.

Biragyn A, Ferrucci L.  Lancet Oncol. Jun 2018.

COMMENT: Ageing reduces the diversity and density of beneficial commensals in the gut, which control pathogens and maintain intestinal barrier integrity through the production of mucus and lipid metabolites, such as short-chain fatty acids. In this... + info

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.
10/06/2018
Publication

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.

Wang J, Kurilshikov A, Radjabzadeh D, Turpin W, Croitoru K, Bonder MJ, Jackson MA, Medina-Gomez C, Frost F, Homuth G, Rühlemann M, Hughes D, Kim HN, Spector TD, Bell JT, Steves CJ, Timpson N, Franke A, Wijmenga C, Meyer K, Kacprowski T, Franke L, Paterson AD, Raes J, Kraaij R, Zhernakova A.  Microbiome. Jun 2018. doi: 10.1186/s40168-018-0479-3.

COMMENT: In this article the authors announce the MiBioGen consortium initiative, the largest consortium to date devoted to microbiota-GWAS, which has assembled 18 population-level cohorts and some 19,000 participants. Its aim is to generate... + info

Leveraging Existing 16S rRNA Gene Surveys To Identify Reproducible Biomarkers in Individuals with Colorectal Tumors.
07/06/2018
Publication

Leveraging Existing 16S rRNA Gene Surveys To Identify Reproducible Biomarkers in Individuals with Colorectal Tumors.

Sze MA, Schloss PD.  MBio. Jun 2018.

COMMENT: Colorectal cancer (CRC) is a growing worldwide health problem in which the microbiota has been hypothesized to have a role in disease progression. Numerous studies using murine models of CRC have shown the importance of both individual... + info

Impact of dietary gut microbial metabolites on the epigenome.
04/06/2018
Publication

Impact of dietary gut microbial metabolites on the epigenome.

Gerhauser C.  Philos Trans R Soc Lond B Biol Sci. Jun 2018.

COMMENT: Multiple dietary compounds have been shown to be involved in epigenome modifications: from DNA to histones modifications, raising the interest in them as putative players in the prevention of certain diseases as cancer; diseases where... + info

Relationships Between Perinatal Interventions, Maternal-Infant Microbiomes, and Neonatal Outcomes
01/06/2018
Publication

Relationships Between Perinatal Interventions, Maternal-Infant Microbiomes, and Neonatal Outcomes

Valentine G, Chu DM, Stewart CJ, Aagaard KM.  Clin Perinatol. Jun 2018 doi https://doi.org/10.1016/j.clp.2018.01.008.

COMMENT: It is widely described the relation of the human microbiome with human common diseases like obesity, type II diabetes and inflammatory bowel disease to name a few. It is also thought that this relation might start in early life during... + info

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