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August 2018

Interaction between the microbiome and TP53 in human lung cancer.
21/09/2018
Publication

Interaction between the microbiome and TP53 in human lung cancer.

Greathouse KL, White JR, Vargas AJ, Bliskovsky VV, Beck JA, von Muhlinen N, Polley EC, Bowman ED, Khan MA, Robles AI, Cooks T, Ryan BM, Padgett N, Dzutsev AH, Trinchieri G, Pineda MA, Bilke S, Meltzer PS, Hokenstad AN, Stickrod TM, Walther-Antonio MR, Earl JP, Mell JC, Krol JE, Balashov SV, Bhat AS, Ehrlich GD, Valm A, Deming C, Conlan S, Oh J, Segre JA, Harris CC.  Genome Biol. 08 2018. doi: 10.1186/s13059-018-1501-6.

The authors suggest the interaction between the lung microbiome and the host tissue in lung cancer, particularly in squamous cell carcinoma cases with certain TP53 mutations. By means of 16S analysis, RNA-Seq sequencing and fluorescent in situ hibridization... + info

Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition.
23/08/2018
Publication

Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition.

Fulde M, Sommer F, Chassaing B, van Vorst K, Dupont A, Hensel M, Basic M, Klopfleisch R, Rosenstiel P, Bleich A, Bäckhed F, Gewirtz AT, Hornef MW.  Nature. Aug 2018. doi: 10.1038/s41586-018-0395-5.

COMMENT: This publication shows how TLR5, a member of the Toll-like receptors that plays a fundamental role in pathogen recognition and activation of innate immune responses, is a key factor in the shaping of the peculiarities of the individual microbiota... + info

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