Urinary microbiota - a potential biomarker and therapeutic target for bladder cancer.

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PubMed ID: 31418671

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Bi H, Tian Y, Song C, Li J, Liu T, Chen Z, Chen C, Huang Y, Zhang Y

J Med Microbiol. Aug 2019. doi: 10.1099/jmm.0.001058

COMMENT: In this study 29 bladder cancer patients and 26 non-cancer patients were collected prior to antibiotic administration to analyze their urinary microbiota. The authors detected some differences that suggest that urine microbiome could be used as biomarker and therapeutic target.

The microbiome as potential biomarker has been proposed in different types of cancer using different types of samples as tumor microbiome, blood microbiome, fecal microbiome, oral microbiome or others. This study is focused on urinary microbiota. Probably the low charge of bacteria of urine samples makes easier to find associations of cancer with the presence of specific taxa. 

More and more publications reports the importance and the impact of microbiome in cancer and this is a new interesting one.


Comparing the microbiota between the bladder cancer and control group, five genera of bacteria (Streptococcus, Bifidobacterium, Lactobacillus, Veillonella and Actinomyces) existed in all samples, but with significant intergroup differences (P<0.05). The bladder cancer patients presented with a higher abundance of Actinomyces, while the other strains were enriched in the control group. A higher abundance of Actinomyces europaeus was also observed in the bladder cancer group compared to the control group. . .

The urinary microbiota may be a potential biomarker and therapeutic target for bladder cancer.



Raquel Tobes