Towards an Individualized Nutrition Treatment: Role of the Gastrointestinal Microbiome in the Interplay Between Diet and Obesity.
Adalsteinsdottir SA, Magnusdottir OK, Halldorsson TI, Birgisdottir BE
Curr Obes Rep. Dec 2018. doi: 10.1007/s13679-018-0321-z
COMMENT: This review is focused on the relationship between microbiome and obesity. The review includes new evidences about the influence of microbiome on energy metabolism and studies about communication between host and gastrointestinal microbiome and about how the food choices and environmental challenges influence this bidirectional communication.
Studies indicate that each individual digests and metabolizes identical food substances differently dependent on composition of their GI microbiome. On the other hand, diet itself seems to play a vital role in formation and health of the GI microbiome through a molding effect over time, making diet history an important tool in an individualized treatment
...interventions with appropriate design are needed including to investigate whether the GI microbiome is an instrumental agent in dealing with energy balance and appetite and, on a larger scale, the gut-brain axis and balance of SCFA
Future aim should be to create personalized, non-invasive dietary treatment with focus on prevention in the long term.