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Tongue coating microbiome data distinguish patients with pancreatic head cancer from healthy controls

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Haifeng Lu, Zhigang Ren, Ang Li, Jinyou Li, Shaoyan Xu, Hua Zhang, Jianwen Jiang, Jiezuan Yang, Qixia Luo, Kai Zhou, Shusen Zheng & Lanjuan Li

Journal of Oral Microbiology, 11:1, Jan 2019. DOI: 10.1080/20002297.2018.1563409

COMMENT: The study reveals differences in the tongue coating microbiome in patients with Pancreatic head carcinoma comparing with Liver cancer patients and healthy controls.

OBJECTIVE

Our aim is to reveal the bacterial composition shifts in the microbiota of the tongue coat of PHC (Pancreatic head carcinoma ) patients

MAIN RESULTS

The microbiome diversity of the tongue coat in PHC patients was significantly increased, (...). Principal component analysis revealed that PHC patients were colonized by remarkably different tongue coating microbiota than healthy controls and liver cancer patients. Linear discriminant analysis effect size revealed that Leptotrichia, Fusobacterium, Rothia, Actinomyces, Corynebacterium, Atopobium, Peptostreptococcus, Catonella, Oribacterium, Filifactor, Campylobacter, Moraxella and Tannerella were overrepresented in the tongue coating of PHC patients, and Haemophilus, Porphyromonas and Paraprevotella were enriched in the tongue coating microbiota of healthy controls. Strikingly, Haemophilus, Porphyromonas, Leptotrichia and Fusobacterium could distinguish PHC patients from healthy subjects, and Streptococcus and SR1 could distinguish PHC patients from liver cancer patients.

CONCLUSIONS

These findings identified the microbiota dysbiosis of the tongue coat in PHC patients, and provide insight into the association between the human microbiome and pancreatic cancer.

Contributor

Marina Manrique