The intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics.
Camara-Lemarroy CR, Metz L, Meddings JB, Sharkey KA, Wee Yong V
Brain. Jul 2018. doi: 10.1093/brain/awy131
COMMENT: This review is focused on the role that the gut microbiome and the intestinal barrier could play in the pathophysiology of multiple sclerosis. In several works it has been reported that some gastrointestinal disorders with intestinal barrier breakdown show evidence of CNS demyelination, probably due to the impact on the functions of CNS microglia that the microbial organisms entering in the circulation provoke.
The authors highlight the importance of the intestinal barrier and the mucosal immune cells in the brain-gut axis and describe this host-microbiome interface as a crucial zone of interaction between immune cells and microbial cells:
In this review, we describe the intestinal barrier as the physical and functional zone of interaction between the luminal microbiome and the host. Besides its essential role in the regulation of homeostatic processes, the intestinal barrier contains the gut mucosal immune system, a guardian of the integrity of the intestinal tract and the whole organism.
Barrier-stabilizing strategies of treatment for multiple esclerosis as probiotics and stabilizers of tight junctions are discussed along the review and proposed as new therapeutic possibilities for multiple esclerosis.