The gastrointestinal fate of limonin and its effect on gut microbiota in mice.

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PubMed ID: 31418448

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Gu M, Sun J, Qi C, Cai X, Goulette T, Song M, You X, Sela DA, Xiao H

Food Funct. Aug 2019. doi: 10.1039/c9fo01274e

COMMENT: In this work the authors study the effect of Limonin, widely found in citrus fruits, in the mice microbiome. Mice were fed with a diet containing 0.05% limonin for 9 weeks. Using liquid chromatography-mass spectrum analysis they showed that limonin reached 523.14 nmol g-1 in colon.

As result of the comparison of limonin-fed to control mice they found that colonic microbiome richness was significantly increased by limonin.

Principle Coordinate Analysis showed the control group and the limonin-fed  group as 2 different groups. Relative abundance of 22 genera was altered significantly in limonin-group compared to control group.


Within the infectious disease category, bacterial toxin and Staphylococcus aureus infection markers were suppressed significantly with limonin treatment. Collectively, our study provides the first line of evidence that oral intake of limonin could shift gut microbiota composition and its functions, which warrants further investigation to determine its implication in human health.


Raquel Tobes