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The gastric mucosal-associated microbiome in patients with gastric polyposis.

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PubMed ID: 30217998

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Ren R, Wang Z, Sun H, Gao X, Sun G, Peng L, Yan B, Yang Y

Sci Rep. Sep 2018. doi: 10.1038/s41598-018-31738-2

COMMENT: In this study the authors analyze the gastric microbiota in patients with gastric polyposis and compare it to the microbiota from healthy controls. Based on the results obtained they construct a microbial dysbiosis index (MDI) able to distinguish individuals in the GP (gastric polyposis) and HC (Healthy control) groups.

OBJECTIVE

In this study, we analyzed the gastric bacterial community composition and diversity characteristics of patients with gastric polyps. In addition, we constructed a microbial dysbiosis index (MDI) model which was able to predict gastric polyps based on the bacterial profles of gastric.

MAIN RESULTS

The results showed that the diversity of the gastric fora in the GP (gastric polyposis) group was signifcantly lower than that of the HC (Healthy Control) group. The gastric fora composition of the GP group was signifcantly diferent from the HC group. However, fora diversity and compositions in diferent parts of the stomach (gastric antrum, gastric body or polyp tissue) were not signifcantly diferent. H. pylori abundance could infuence the composition of gastric microbiota. Meanwhile, patients with fundic gland polyps (FGPs) and those with hyperplastic polyps (HPs) had considerably similar gastric bacterial compositions.

CONCLUSIONS

We constructed a microbial dysbiosis index (MDI) based on the gastric microbiota at the genus level as a predictive model, and it was able to distinguish between individuals in the GP and HC groups. These fndings showed that intragastric fora dysbiosis may be closely related to the occurrence and development of gastric polyps.

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Marina Manrique