The fecal and mucosal microbiome in acute appendicitis patients: an observational study.
Peeters T, Penders J, Smeekens SP, Galazzo G, Houben B, Netea MG, Savelkoul PH, Gyssens IC
Future Microbiol. Jan 2019. doi: 10.2217/fmb-2018-0203
OBJECTIVE: This study is focused to the analysis of differences between intestinal microbiota of appendicitis patients and healthy individuals.
RESULTS: Fecal and mucosal microbiota of the appendix from patients and healthy controls are analyzed and differences were found only in the appendiceal microbiota:
Overall fecal microbial richness and diversity were similar in patients and controls, yet richness and diversity within the group of Firmicutes, Actinobacteria, Fusobacteria and Verrucomicrobia phyla were lower in patients. Discriminant analyses could correctly classify patients and controls with fair accuracy. No differences were found according to severity in appendiceal or fecal microbiota
CONCLUSIONS: Detected differences in the composition of intestinal microbiota of appendicitis patients and healthy individuals allow to correctly classify patients and controls included in the study using Discriminant analysis statistical methods.