Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth.

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PubMed ID: 31534227

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Shao Y, Forster SC, Tsaliki E, Vervier K, Strang A, Simpson N, Kumar N, Stares MD, Rodger A, Brocklehurst P, Field N, Lawley TD

Nature. Sep 2019. doi: 10.1038/s41586-019-1560-1

COMMENT: This study analyzes the microbiome of 596 full-term babies, 314 of them were vaginal births and 282 were via caesarean section. The analysis was mainly done using shotgun metagenomics approaches.  The results of this work confirm recent findings that showed the mode of delivery as a major factor that shapes the gut microbiome in the first weeks of the newborn with some slight effects that remain during infancy. In a subset of 178 babies, transmission of bacterial strains was also analyzed within each mother–baby dyad.

The main compositional difference in the microbiome of the babies delivered by caesarean section was a low abundance or absence of Bacteroides species that was detected in 99.6% (281 out of 282) babies delivered by caesarean section.


Raquel Tobes