Relationship between intestinal microbial dysbiosis and primary liver cancer.
Zhang L, Wu YN, Chen T, Ren CH, Li X, Liu GX
Hepatobiliary Pancreat Dis Int. Jan 2019
The present study aimed to study the changes in intestinal flora at various stages of PLC (Primary Liver Cancer) and clarify the relationship between intestinal microbes and PLC.
Diversity of Firmicutes tended to decrease from the HC (Healthy Control) to LC (Liver Cirrhosis) and PLC groups at the phylum level.(...) The ratio of Firmicutes/Bacteroidetes was significantly decreased with the disease progression. In addition, the linear discriminant analysis effect size method indicated that Clostridia were predominant in the gut microbiota of the HC group, whereas Enterococcaceae, Lactobacillales, Bacilli and Gammaproteobacteria may be used as diagnostic markers of PLC.
This study indicates that dysbiosis of the gut microbiota might be involved in PLC development and progression.