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Oral Nickel Changes of Intestinal Microflora in Mice.

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PubMed ID: 30859288

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Zhou X, Li J, Sun JL

Curr Microbiol. Mar 2019. doi: 10.1007/s00284-019-01664-1

COMMENT: In this work, the authors investigate the effect of oral nickel administration on intestinal microbiome in mice to support some preliminary studies that link the dietary nickel with modifications in the gut microflora. 

MAIN RESULTS:

No significant difference in body weight was found between the control group (Group C) and the oral nickel group (Group O) before and after the nickel exposure. 

Mice treated with nickel showed a significantly higher nickel content in the kidney compared to mice treated with pure water. 

Relative abundance of Bacteroidetes was higher in the oral nickel group whereas the relative abundance of Firmicutes and the ratio Firmicutes / Bacteroides was lower in comparison with the control group. 

At the genus level, a significantly higher relative abundance of Bacteroides and Intestinimonas and a lower relative abundance of Lachnospiraceae was observed in the oral nickel group compared to the control group. 

CONCLUSION:

(...) the community structure of the intestines in mice was changed after oral nickel exposure. We also found the strain S24-7, which is unique to the oral nickel group, and we screened out the differential bacteria belonging to the oral nickel, mainly Bacteroides, Intestinimonas, Lachnospiraceae_NK4A136_ group and Lachnospiraceae_UCG-001. These bacteria are inextricably linked to immunity and they exert anti-inflammatory or pro-in ammatory effects. Future studies should include more rigorous testing to accurately analyze the functions of these bacteria in animal models of different states and through intervention trials of different populations. To utilize the beneficial role of these bacteria, the unique bacterial group S24-7 in the oral nickel should be further investigated. 

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Raquel Ruiz-Arroyo