Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls.
Chen J, Chia N, Kalari KR, Yao JZ, Novotna M, Soldan MM, Luckey DH, Marietta EV, Jeraldo PR, Chen X, Weinshenker BG, Rodriguez M, Kantarci OH, Nelson H, Murray JA, Mangalam AK
Sci Rep. Jun 2016. doi: 10.1038/srep28484
According to the “hygiene hypothesis”, reduced exposure to infections in childhood may increase the risk of allergic and autoimmune diseases. Patients with active disease and those in remission were compared with controls. There was a trend towards lower species richness in patients with active disease compared to healthy controls. Thus, MS patients had dysbiosis of fecal microbiota in the gut. The authors did'nt find any effect of factors such as smoking, family history, or treatment status on abundance of microbiota.