Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations.
Thaiss CA, Levy M, Korem T, Dohnalová L, Shapiro H, Jaitin DA, David E, Winter DR, Gury-BenAri M, Tatirovsky E, Tuganbaev T, Federici S, Zmora N, Zeevi D, Dori-Bachash M, Pevsner-Fischer M, Kartvelishvily E, Brandis A, Harmelin A, Shibolet O, Halpern Z, Honda K, Amit I, Segal E, Elinav E
Cell. Dec 2016
The authors investigate diurnal oscillations of the Microbiome and demonstrates that Microbiota diurnal rhythmicity programs host transcriptome oscillations.
They found that epithelial layer adherence in the dark phase is up to 10-fold higher than in the light phase and the global bacterial composition was also different in those phases. The bacterial community at the intestinal mucosa at any time point was more similar to the one present 24 hr earlier, the same time the day before, than to any other time point in between.
Doing metagenomics analysis of the mucosal microbial community every 6 hr along 48 hr. they found rhythmic changes in the abundance of genes involved in pathways related to mucus degradation and bacterial motility.
Host circadian rhythms was shown indispensable for the maintenance of microbiota biogeographical rhythms and it was because the access to food. Mice that were fed either only during the dark or only during the light period showed phase-reversed microbial attachment rhythms
Furthermore, they reported how the microbiota programs the hepatic transcriptome through systemic metabolome oscillations.