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Microbiota and Pathogen Proteases Modulate Type III Secretion Activity in Enterohemorrhagic Escherichia coli.

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PubMed ID: 30514785

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Cameron EA, Curtis MM, Kumar A, Dunny GM, Sperandio V

MBio. 12 2018

COMMENT: This work describes how the commensal Bacteroides thetaiotamicron secretes proteases that cleave the translocon of the Type 3 Secretion System (T3SS) of Enterohemorrhagic Escherichia coli (EHEC) and, thus, enhances effector translocation into host cells increasing the severity of the disease caused by EHEC.

This is the first demonstration of a commensal species directly processing a pathogen's T3SS, posing a new paradigm for how the microbiota can influence the severity of disease caused by bacterial pathogens.

We are starting to unravel the mechanisms by which different microbiota membership can either offer resistance or aid invading pathogens.

Therefore, proteolytic cleavage by microbiota-derived or endogenous proteases may be a factor broadly affecting T3SSs. This presents a new paradigm for how the microbiota may shape disease progression by pathogens.

 

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Raquel Tobes