Microbiome at the Frontier of Personalized Medicine.
Kashyap PC, Chia N, Nelson H, Segal E, Elinav E
Mayo Clin Proc. Dec 2017
COMMENT: This is a review explaining how Microbiome is today part of Personalized Medicine. The genomic revolution has provided a window into individual-specific information and its effect on human physiology, opening the way for personalized or precision medicine. The advent of Microbiome research has identified the Microbiome as an important contributor to human health, and in this review we highlight why the microbiome is an integral component of the precision medicine initiative.
The authors summarizes the idea:
Gut microbiome as a determinant of human health and response to therapeutic intervention. The gut microbiome plays an important role in an individual’s response to interventions ranging from dietary and lifestyle changes to medications and surgical interventions; hence, in addition to host genetics, it is important to consider the role of the gut microbiome in selecting appropriate therapy. The gut microbiome, unlike host genes, represents a modifiable factor that can be targeted by probiotics, prebiotics, diet, as well as community replacement approaches such as fecal microbiota transplant.
And they conclude:
Microbial fingerprints could serve as precise, noninvasive, accessible, and economic tools that could be used for personalized disease diagnosis including phenotypes, severity, and prognosis. The role of themicrobiome in the metabolism of many chemical compounds makes it a key player in determining drug availability, efficacy, and toxicity, making it indispensable for developing personalized drug therapies