Microbial modulation of cardiovascular disease.
Brown JM, Hazen SL
Nat Rev Microbiol. Jan 2018. doi: 10.1038/nrmicro.2017.149
COMMENT: For years now it is known the importance of diet in the development of cardiovascular disease (CVD). It is now widely admitted in the scientific community that the human microbiota might play a role in the CVD development as well.
The article reviews the relationship between human microbiome and the CVD development and pathogenesis. It is suggested that the microbiome might affect the CDV development and pathogenesis via these two mechanisms:
- Through Microorganism-associated molecular patterns which are recognized by host pattern recognition receptors like the NOD1, TLR2, TLR3, TLR4, TLR7 and TLR9 proteins.
- Via metabolites produced by the gut microorganisms. These metabolites might act locally or systemically as they might be incorporated to the blood stream and distributed along the whole organism. The main metabolites linked to the CVD development are trimethylamines, short chain fatty acids (SCFAs) and secondary bile acids.
The review remarks the importance of the use of multiomics technologies to detect microbial derived products that might be playing a role in the CVD development and pathogenesis. Once these products are identified they could be potential targets for drug discovery.