Metagenomic and metatranscriptomic analysis of human prostate microbiota from patients with prostate cancer.
Feng Y, Ramnarine VR, Bell R, Volik S, Davicioni E, Hayes VM, Ren S, Collins CC
BMC Genomics. Feb 2019. doi: 10.1186/s12864-019-5457-z
COMMENT: The authors analyze the prostate microbiome of tumoral and benign adjacent tissue of 65 prostate cancer patients by means of metagenomics and metatranscriptomics. Even though the authors do not find strong correlations between prostate microbiome and tissue type (tumoral or benign) they do find strong correlation between the expression of certain Pseudomonas genes and host miRNA involved in metastasis.
The aim of this study was to characterize the microbiome in prostate tissue of PCa patients and investigate its association with tumour clinical characteristics as well as host expression profiles
The biodiversity of the microbiomes could not be differentiated between the matched tumour/benign specimens or between the tumour specimens of low and high Gleason Scores. The expression profile of ten Pseudomonas genes was strongly correlated with that of eight host small RNA genes; three of the RNA genes may negatively associate with metastasis.
In this Chinese cohort, both metagenome and metatranscriptome analyses showed a non-sterile microenvironment in the prostate of PCa patients, but we did not find links between the microbiome and local progression of PCa. However, the correlated expression of Pseudomonas genes and human small RNA genes may provide tantalizing preliminary evidence that Pseudomonas infection may impede metastasis.