Maternal diet during pregnancy is related with the infant stool microbiome in a delivery mode-dependent manner.
Lundgren SN, Madan JC, Emond JA, Morrison HG, Christensen BC, Karagas MR, Hoen AG
Microbiome. 07 2018. doi: 10.1186/s40168-018-0490-8
COMMENT: This work was designed to study the association of maternal diet during pregnancy with the infant gut microbiome. For that, microbiomes of the children and diet of the mothers were analyzed at 6 weeks post-delivery in 145 mother-infant dyads enrolled in the New Hampshire Birth Cohort Study.
Targeted sequencing of the 16S rRNA V4-V5 hypervariable region was used to analyze infant gut microbiomes. Stratification by delivery mode was considered in the analysis.
Analyzing the results of the taxonomic profiling of the infant microbiome, overall and in the vaginally delivered infant stratum, the authors identified 3 groups characterized by the predominance of different taxa:
- Group with increased abundance of Bifidobacterium
- Group with increased abundance of Streptococcus and Clostridium
- Group withi ncreased abundance of Bacteroides
In the vaginally delivered infant stratum maternal fruit intake was associated with infant gut microbial community structure detecting a predominance of belonging to Streptococcus/Clostridium group.
In infants delivered by Cesarean section, the authors identified three groups slightly different from those identified in vaginally delivered infants:
- Group with high abundance of Bifidobacterium
- Group with high Clostridium and low Streptococcus and Ruminococcus genera
- Group with high abundance of the family Enterobacteriaceae
Maternal dairy intake was associated with higher belonging to the high Clostridium cluster in infants born by Cesarean section.
The authors conclude:
Our data indicate that maternal diet influences the infant gut microbiome and that these effects differ by delivery mode