Maternal Administration of Probiotic or Prebiotic Prevents Male Adult Rat Offspring against Developmental Programming of Hypertension Induced by High Fructose Consumption in Pregnancy and Lactation.
Hsu CN, Lin YJ, Hou CY, Tain YL
Nutrients. Sep 2018
COMMENT: This work is centred on the study in rats of the hypertension that maternal high-fructose (HF) diet can induce in her adult male offspring. Considering that the effect of HF-induced programmed hypertension could be mediated by microbiome alteration, the authors tried to determine whether microbiome-targeted therapies could be efficacious. They used probiotic Lactobacillus casei and prebiotic inulin:
Maternal probiotic Lactobacillus casei and prebiotic inulin therapies protect against hypertension in male adult offspring born to fructose-fed mothers. Probiotic treatment prevents HF-induced hypertension is associated with reduced plasma acetate level and decreased renal mRNA expression of Olfr78
The authors conclude that maternal gut microbiota-targeted therapies could be useful to prevent the development of hypertension caused by maternal consumption of fructose-rich diet.