Linkages between oral commensal bacteria and atherosclerotic plaques in coronary artery disease patients
Jyoti Chhibber-Goel, Varsha Singhal, Debaleena Bhowmik, Rahul Vivek, Neeraj Parakh, Balram Bhargava and Amit Sharma. npj Biofilms and Microbiomes (2016) 2:7 ; doi:10.1038/s41522-016-0009-7.
COMMENT: This study is meta-analysis from published studies about the presence of bacteria within atherosclerotic plaque in coronary disease patients.
The study covered 1791 patients. In their atherosclerotic plaques 23 oral commensal bacteria were detected. The oral bacteria Campylobacter rectus, Porphyromonas gingivalis, Porphyromonas endodontalis, Prevotella intermedia, Prevotella nigrescens were uniquely detected in coronary plaques and not in other tissues.
The authors highlight the detection of specific poly-microbial communities within atherosclerotic plaques.
The majority of bacteria detected in the atherosclerotic plaque were Gram-negative bacteria with the exception of the Gram-positive Streptococcus sp.
Atherosclerotic plaque-associated bacteria include facultative anaerobes as Aggregatibacter actinomycetemcomitans, Campylobacter rectus, Eikenella corrodens, Enteroacter hormaechei, Streptococcus gordonii, Streptococcus mitis, Streptococcus mutans, Streptococcus oralis, Streptococcus sanguinis, Helicobacter pylori, and Pseudomonas aeruginosa and obligatory anaerobes as Chlamydiae pneumoniae, Fusobacterium necrophorum, Fusobacterium nucleatum, Mycoplasma pneumoniae, Porphyromonas endodontalis, Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigrescens, Treponema denticola, and Tannerella forsythia.
We can find new connections between oral microbiome and atherosclerotic plaque in this work.