Ketonuria Is Associated with Changes to the Abundance of Roseburia in the Gut Microbiota of Overweight and Obese Women at 16 Weeks Gestation: A Cross-Sectional Observational Study.
Robinson H, Barrett H, Gomez-Arango L, McIntyre HD, Callaway L, Dekker Nitert M
Nutrients. Aug 2019
COMMENT: This work was oriented to analyze the differences in the composition of the gut microbiota in pregnant women with and without ketonuria at 16 weeks gestation using 16S-based taxonomic profiling. The study includes 11 women with fasting ketonuria and 11 matched controls.
The authors found differences between the microbiome composition of both groups and highligthed the high abundance of Roseburia in the pregnant women with ketonuria:
The bacteria that contributed the most to the differences in the composition of the gut microbiota included Roseburia, Methanobrevibacter, Uncl. RF39, and Dialister in women with ketonuria and Eggerthella, Phascolarctobacterium, Butyricimonas, and Uncl. Coriobacteriaceae in women without ketonuria. This study found that the genus Roseburia is more abundant in the gut microbiota of pregnant women with ketonuria. Roseburia is a butyrate producing bacterium and may increase serum ketone levels.