Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children.

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PubMed ID: 26811868

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Korpela K, Salonen A, Virta LJ, Kekkonen RA, Forslund K, Bork P, de Vos WM

Nat Commun. 2016. doi: 10.1038/ncomms10410

COMMENT: It has been described that to take antibiotics in the childhood is associated with increased risk for inflammatory bowel disease, overweight and asthma.

The authors describe how children treated with antibiotics have changes in their microbiome that persist for over 6 months. But not all antibiotics do the same: macrolides seems to affect the more the microbiome and predispose for increased BMI (body mass index) and risk of having asthma. On the other hand, penicillins have less impact in the microbiome.

They also describe the change in the microbiome that includes a depletion of Actinobacteria and an increase in Bacteroidetes and Proteobacteria.


Eduardo Pareja