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Impact of Early Exposure to Cefuroxime on the Composition of the Gut Microbiota in Infants Following Cesarean Delivery.

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PubMed ID: 31053348

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Kamal SS, Hyldig N, Krych Ł, Greisen G, Krogfelt KA, Zachariassen G, Nielsen DS

J Pediatr. Jul 2019

COMMENT: The goal of this work was to assess in cesarean deliveries if prophylactic antibiotics have some impact on gut microbiota colonization or in antibiotic susceptibility of the gut bacteria in the newborn.

Forty-two pregnant women scheduled for cesarean delivery were recruited and randomly assigned to receive cefuroxime. Fecal samples from the newborns were collected at age 10 days and 9 months. The bacterial composition of the microbiome were analyzed using 16S approaches. These were the main conclusions:

No clear difference in the composition of the gut microbiota was observed between infants whose mothers received cefuroxime before or after cesarean delivery at neither time point, though surprisingly at 9 months of age, but not at 10 days of age, the number of observed species was higher in infants where mothers received cefuroxime after cord clamping. No differences in antimicrobial susceptibility of Enterobacteriaceae, Enterococcus spp, and Staphylococcus spp were seen at 10 days. Timing of cefuroxime administration to mothers undergoing cesarean delivery does not have a major effect on the gut microbiota and bacterial antibiotic resistance traits in infants.

Clinicaltrials.gov: NCT02072798.

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Raquel Tobes