Impact of dietary gut microbial metabolites on the epigenome.
Philos Trans R Soc Lond B Biol Sci. Jun 2018
COMMENT: Multiple dietary compounds have been shown to be involved in epigenome modifications: from DNA to histones modifications, raising the interest in them as putative players in the prevention of certain diseases as cancer; diseases where the epigenome might play an important role.
Evidences of the implication of the gut microbiome in the metabolism and bioavailability of such compounds have recently increased. This review summarizes the articles published about how the microbiome might be involved in the diet-epigenome interactions, especially in the metabolism of compounds like folate and B-vitamins, dietary polyphenols, dietary fibers and dietary long-chain omega3 fatty acids.
The author concludes with the importance of multidisciplinary studies able to decipher the complex host-microbiome interactions that might be responsible for the effects of such compounds in the epigenome modulation.