Human Milk Oligosaccharides and Immune System Development.

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PubMed ID: 30096792

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Plaza-Díaz J, Fontana L, Gil A

Nutrients. Aug 2018

COMMENT: This review is centred on Human Milk Oligosaccharides (HMOs), key components of maternal human milk. 

HMOs has been involved in important functions as:

  • to inhibit the adhesion of microorganisms to the intestinal mucosa
  • to avoid the growth of pathogens
  • to inhibit the expression of genes involved in inflammation
  • to modulate immune system development

These functions are discussed in this review with especial attention to those related to pathogens gut colonization and immune system:

This review begins with short descriptions of the basic structures of HMOs and the gut immune system, continues with the beneficial effects of HMOs shown in cell and animal studies, and it ends with the observational and randomized controlled trials carried out in humans to date, with particular emphasis on their effect on immune system development.


Raquel Tobes