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High-Fat Diet Changes Fungal Microbiomes and Interkingdom Relationships in the Murine Gut.

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PubMed ID: 29034327

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Heisel T, Montassier E, Johnson A, Al-Ghalith G, Lin YW, Wei LN, Knights D, Gale CA

mSphere.

COMMENT: This study, using a mouse model, associates a high-fat diet with changes in the fungal and bacterial microbiome and finds interkingdom structural and functional relationships between fungi and bacteria abundances after a high-fat diet treatment.

These detected relationships between the bacterial and the fungal microbiome composition could be based on their capabilities of metabolizing fat. Some types of bacteria and fungi change after high-fat diet: 

For bacteria, mice fed a high-fat diet had increased Bacteroides, Enterococcus, Proteus, Lactobacillus, Ruminococcaceae, Streptococcus, Christensenellaceae, and Allobaculum numbers and decreased Prevotella, Anaeroplasma, Erysipelotrichaceae, Turicibacter, and Candidatus Arthromitus numbers  compared to mice fed standard chow. 

For fungi, the abundances of  the Alternaria, Saccharomyces, Septoriella, and Tilletiopsis genera; Saccharomyces cerevisiae; and Tilletiopsis washingtonensis were higher in mice fed standard chow (FDR-corrected P value of <0.05), while no taxa were significantly higher in mice fed the high-fat chow.

In this study the fungal abundances were analyzed sequencing ITS regions.

This work announces that probably it is the time to analyze both bacteria and fungi to have a more complete scenario of the gut microbiome.

Contributor

Raquel Tobes