Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs.
Javaheri A, Kruse T, Moonens K, Mejías-Luque R, Debraekeleer A, Asche CI, Tegtmeyer N, Kalali B, Bach NC, Sieber SA, Hill DJ, Königer V, Hauck CR, Moskalenko R, Haas R, Busch DH, Klaile E, Slevogt H, Schmidt A, Backert S, Remaut H, Singer BB, Gerhard M
Nat Microbiol. Oct 2016. doi: 10.1038/nmicrobiol.2016.189
COMMENT: Helicobacter pylori is an important human pathogen and causes gastric cancer. Some proteins that bind blood group factors facilitate H. pylori persistence. The authors observed that H. pylori is able to bind gastric epithelium of non-secretors. Thus, other factors could be involved in H. pylori binding. In the article, they demonstrate that H. pylori adhesin HopQ specifically interacts with human carcinoembryonic antigen-related cell adhesion molecules (CEACAMs).
The interaction showed to be strongly species-specific, since they found that H. pylori bound selectively to human, but not to mouse, bovine or canine CEACAM1 orthologues. Interestingly, H. pylori does interact with rat CEACAM. Immunoprecipitation experiments showed that the H. pylori molecule responsible for CEACAM binding was the outer membrane protein HopQ.
Using a rat model of H. pylori infection, the authors showed that a strain deficient in HopQ was not able to colonize rats. In summary, this molecular interaction seems to be important in the pathogenic effects of H. pylori.