Four-week administration of nicotine moderately impacts blood metabolic profile and gut microbiota in a diet-dependent manner.

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PubMed ID: 31100541

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Wang R, Li S, Jin L, Zhang W, Liu N, Wang H, Wang Z, Wei P, Li F, Yu J, Lu S, Chen Y, Li Z, Wu C

Biomed Pharmacother. May 2019

COMMENT: In this work the authors analyze, in mice, the impact of nicotine on hyperlipidemia and hyperglycemia and the changes that it induces on gut microbiome in 2 different scenarios: normal chow diet (NCD)- and high-fat diet (HFD)-fed mice. Interesting results show that nicotine administration impacts gut microbiome (increased Ruminococcaceae) and is related to higher lipid and glucose blood levels especially in high-fat diet in mice. Antibiotics co-treatment substantially abolishes the lipid-enhancing effect of nicotine, suggesting that this metabolic effect is mediated by gut microbiome.

In the present study, we assessed the impacts of nicotine on blood lipid and glucose profile and on the gut microbiota in both normal chow diet (NCD)- and high-fat diet (HFD)-fed mice. Our data showed that oral administration of nicotine imposed more profound influences on plasma lipids, glucose and inflammatory factors in HFD-fed mice than in NCD animals.

…the gut microbiota plays an important role in nicotine-induced lipid- and glucose-dysregulation,as the enhancing effects of nicotine on serum TG, LDL-c and glucose levels  were  substantially abolished  when  combined with antibiotics.


Together, we found that intake of nicotine imposes more harmful effects on blood lipid and glucose as well as systemic inflammation in animals fed with HFD than that eating NCD. Chronic exposure to nicotine significantly alters the gut microbiota especially in HFD condition.


Raquel Tobes