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Fecal and blood microbiota profiles and presence of nonalcoholic fatty liver disease in obese versus lean subjects.

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PubMed ID: 30870486

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Yun Y, Kim HN, Lee EJ, Ryu S, Chang Y, Shin H, Kim HL, Kim TH, Yoo K, Kim HY

PLoS One. 2019. doi: 10.1371/journal.pone.0213692

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver diseases. In this work, the authors investigate the association between fecal and blood microbiome profiles in people obese versus lean with or without NAFLD, sequencing the 16S rRNA gene (V3-V4 region).

They analyzed the microbiomes of fecal and blood samples from 268 participants, 76 of them diagnosed with NAFLD.

They observed that lean subjects with NAFLD showed different profiles in blood and gut microbiota compared with obese subjects with NAFLD, also lean subjects showed differences in the blood microbiome in terms of the presence or not of NAFLD.

In the gut microbiota, the decrease in Desulfovibrionaceae was associated with NAFLD in the lean NAFLD group (log2 coefficient (coeff.) = -2.107, P = 1.60E-18), but not in the obese NAFLD group (log2 coeff. = 1.440, P = 1.36E-04). In the blood microbiota, Succinivibrionaceae showed opposite correlations in the lean (log2 coeff. = -1.349, P = 5.34E-06) and obese NAFLD groups (log2 coeff. = 2.215, P = 0.003). Notably, Leuconostocaceae was associated with the obese NAFLD in the gut (log2 coeff. = -1.168, P = 0.041) and blood (log2 coeff. = -2.250, P = 1.28E-10).

To sum up, fecal and blood microbiome profiles had different patterns between obese and lean subjects with NAFLD. Microbiome  could be used as potential biomarker in NAFLD.

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Carmen Martín