Factors Affecting Gastrointestinal Microbiome Development in Neonates.
Chong CYL, Bloomfield FH, O'Sullivan JM
Nutrients. Feb 2018
COMMENT: This review is focused on the factors that affect the development of the gastrointestinal (GI) microbiome during prenatal, perinatal to postnatal life.
Different environmental factors that are encountered during this critical period may influence the gut microbial composition, potentially impacting upon later disease risk, such as asthma, metabolic disorder, and inflammatory bowel disease.
The authors discuss the prenatal sterility dogma considering the research data about bacteria detected in meconium, amniotic fluid, and placenta in cases not related with prenatal infection and review the publised data indicating the initiation of maternal-to-offspring microbial colonisation in utero.