Escherichia coli promotes DSS‑induced murine colitis recovery through activation of the TLR4/NF‑κB signaling pathway.
Lu J, Dong B, Chen A, He F, Peng B, Wu Z, Cao J, Li W
Mol Med Rep. Jan 2019. doi: 10.3892/mmr.2019.9848
COMMENT: Intestinal microbiome is critical in inflammatory bowel disease (IBD). This study investigated the effects of Escherichia coli in the dextran sulfate sodium (DSS)‑induced colitis mouse model of IBD. The results obtained in this work using the TLR4‑/‑ knockout mice indicated that E. coli promoted colitis recovery through activation of the TLR4/NF‑κB signaling pathway.
In the present study, E. coli‑treated DSS‑induced BD mice expressed more NF‑κB compared with untreated DSS‑induced BD mice, which suggested that E. coli promoted NF‑κB activation and accelerated inflammation recovery. By contrast, TLR4‑/‑mice showed no significant recovery from colitis, suggesting that E. coli promoted DSS‑induced colitis recovery through activation of the TLR4/NF‑κB signaling pathway.
In conclusion, the presence of normal intestinal flora may be a necessary condition for the recovery of colitis, potentially through activation of the TLR4/NF‑κB signaling pathway. This indicated that host intestinal microbial interactions were critical to colitis recovery. This study provided evidence for the use of intestinal flora to treat IBD.