Enterobacteria vaginal colonization among patients with preterm premature rupture of membranes from 24 to 34 weeks of gestation and neonatal infection risk.

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PubMed ID: 30562580

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Merello M, Lotte L, Gonfrier S, Eleni Dit Trolli S, Casagrande F, Ruimy R, Bongain A

J Gynecol Obstet Hum Reprod. Mar 2019

COMMENT: The aim of this study was to assess, for Premature rupture of membranes (PROM) occurring at 23-34 weeks' gestation, if the presence of ampicillin-resistant enterobacteria in the vaginal microbiome increases the risk of early-onset neonatal infection.

Two groups were constituted according to the vaginal bacteria isolates and the amoxycillin-resistant enterobacteria found. Two groups of newborns were constituted depending on the suspicion of perinatal maternal-fetal bacterial infection (MFI)

The conclusion of this study was that vaginal colonization of untreated ( without prophylaxis using amoxicillin) or amoxycillin-resistant enterobacteria constitutes a major risk factor of neonatal infection.


Raquel Tobes