Enterobacteria vaginal colonization among patients with preterm premature rupture of membranes from 24 to 34 weeks of gestation and neonatal infection risk.
Merello M, Lotte L, Gonfrier S, Eleni Dit Trolli S, Casagrande F, Ruimy R, Bongain A
J Gynecol Obstet Hum Reprod. Mar 2019
COMMENT: The aim of this study was to assess, for Premature rupture of membranes (PROM) occurring at 23-34 weeks' gestation, if the presence of ampicillin-resistant enterobacteria in the vaginal microbiome increases the risk of early-onset neonatal infection.
Two groups were constituted according to the vaginal bacteria isolates and the amoxycillin-resistant enterobacteria found. Two groups of newborns were constituted depending on the suspicion of perinatal maternal-fetal bacterial infection (MFI)
The conclusion of this study was that vaginal colonization of untreated ( without prophylaxis using amoxicillin) or amoxycillin-resistant enterobacteria constitutes a major risk factor of neonatal infection.