Eczema-protective probiotic alters infant gut microbiome functional capacity but not composition: sub-sample analysis from a RCT.
Murphy R, Morgan XC, Wang XY, Wickens K, Purdie G, Fitzharris P, Otal A, Lawley B, Stanley T, Barthow C, Crane J, Mitchell EA, Tannock GW
Benef Microbes. Feb 2019. doi: 10.3920/BM2017.019
COMMENT: In this work the authors analyze the impact of early life probiotic exposure on the composition and functional capacity of infant gut in relation to age, delivery mode, antibiotics, pets and eczema.
650 infant faecal samples, collected at birth, 3, 12, and 24 months were analyzed using a shotgun metagenomic approach as part of a randomised, controlled, 3-arm trial to study the impact of L. rhamnosus HN001, Bifidobacterium animalis subsp. lactis HN019 supplementation on eczema development.
L. rhamnosus HN001 probiotic supplementation was associated with increased overall glycerol-3 phosphate transport capacity and enrichment of L. rhamnosus.
Children who developed eczema had gut microbiota with increased capacity for glycosaminoglycan degradation and flagellum assembly but had no significant differences in microbiota composition or diversity