Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus.
Wang J, Zheng J, Shi W, Du N, Xu X, Zhang Y, Ji P, Zhang F, Jia Z, Wang Y, Zheng Z, Zhang H, Zhao F
Gut. 09 2018. doi: 10.1136/gutjnl-2018-315988
COMMENT: This work is focused on the possible dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus (GDM) and on the potential risks of that for the newborn.
In this study 581 maternal (oral, intestinal and vaginal) and 248 neonatal (oral, pharyngeal, meconium and amniotic fluid) samples were analyzed. Neonates were predominantly delivered by C-section to avoid the bacterial contamination of vaginal delivery.
These were the main results:
The microbiota of pregnant women and neonates was remarkably altered in GDM, with a strong correlation between certain discriminatory bacteria and the oral glucose tolerance test.
The authors observed maternal and neonatal concordance in the microbiota variation. Some viruses were differentially detected in GDM newborns:
....higher abundance of some viruses (eg, herpesvirus and mastadenovirus) were observed in the meconium microbiota of neonates associated with GDM