Dysbiosis a risk factor for celiac disease.
Girbovan A, Sur G, Samasca G, Lupan I
Med Microbiol Immunol. Feb 2017. doi: 10.1007/s00430-017-0496-z
COMMENT: In this review the authors compile important facts affecting Celiac Disease risk and pathogenesis. Interestingly, for example, they report the fact that the HLA genotype seems to influence the gut microbiome. The involvement of Dysbiosis in Celiac Disease pathogenesis is stated by the authors based in previous publications. Dysbiosis seemed also to be a risk factor for Celiac Disease. In addition features related with virulence are higher in the gut microbiome of Celiac Disease patients.
The authors also describe how the microbiota of Celiac Disease patients is characterized by an increase in Gram-negative bacteria and a decrease in Gram-positive bacteria. Another feature of the Celiac Disease gut microbiota is the low level of Bifidobacterium spp.
Sumarizing the authors conclude:
- The human leukocyte antigen genotype influences the gut colonization, while the gut microbiota alteration contributes to the risk of developing celiac disease (CD)
- Both duodenal and colonic dysbiosis are associated with CD.
- The bacterial virulence feature is considered higher in CD patients.
- Probiotics, such as Bdellovibrio bacteriovorus, Lactobacillus spp, and Bifidobacterium, could improve the management of the CD patients.