Development of immune and microbial environments is independently regulated in the mammary gland.
Niimi K, Usami K, Fujita Y, Abe M, Furukawa M, Suyama Y, Sakai Y, Kamioka M, Shibata N, Park EJ, Sato S, Kiyono H, Yoneyama H, Kitazawa H, Watanabe K, Nochi T, Aso H
Mucosal Immunol. 05 2018. doi: 10.1038/mi.2017.90
COMMENT: The goal of this work was to study how the immune and microbial environments of mammary gland protect the mother and the newborn from infectious diseases.
The authors highlight that IgA production and microbiome seem to be independently regulated in the mammary gland:
In particular, the chemokine (C-C motif) ligand 28 and poly-Ig receptor, crucial molecules for the IgA production in milk, were expressed normally in germ-free lactating mice but were almost undetectable in postweaning mothers, regardless of the microflora presence