Comparison of the Gut Microbiota of Centenarians in Longevity Villages of South Korea with Those of Other Age Groups.
Kim BS, Choi CW, Shin H, Jin SP, Bae JS, Han M, Seo EY, Chun J, Chung JH
J Microbiol Biotechnol. Jan 2019. doi: 10.4014/jmb.1811.11023
COMMENT: Several studies have observed connections between gut microbiota and longevity, however discrepancies have been observed due to differences in diet, life style, genetic factors, and analyses methods. In this study, the authors analyze the gut microbiota of centenarians living in four regions of South Korea and compare the results to those of healthy elderly and adults in the same regions and urbanized towns.
The aim of the study is provide comprehensive information of the gut microbiota of centenarians in longevity villages and help to characterize the role of gut microbiota in healthy aging in humans
The gut microbiota were different between subjects in longevity villages and urbanized towns and the different members of gut microbiota obtained from these two groups were detailed at each taxonomic level. The gut microbiota of centenarians was also different to those of elderly and adults in the same regions.
The relative abundance of Firmicutes was found to be considerably higher in subjects from longevity villages than those from urbanized towns, whereas Bacteroidetes was lower.
The differences could be due to differences in diet patterns and living environments.
The dietary characteristics of the centenarians in longevity villages can influence the composition of their gut microbiota.
Different gut microbiota in centenarians were predicted to be associated with the phosphatidylinositol signaling system, glycosphingolipid biosynthesis, and various types of N-glycan biosynthesis. These functions of gut microbiota can be related to the healthy gut environment of centenarians.