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Characterization of oral microbiota in marmosets: Feasibility of using the marmoset as a human oral disease model.

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PubMed ID: 30730898

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Takehara S, Zeredo JL, Kumei Y, Kagiyama K, Fukasawa K, Oshiro A, Ueno M, Kojimahara N, Minakuchi S, Kawaguchi Y

PLoS One. 2019. doi: 10.1371/journal.pone.0207560

COMMENT: Marmoset could be used as an animal model for the study of human oral health. Its dental physiology and relatively short life-span and relatively small size make the marmoset a better animal model over other non-human primates.

The purpose of this study was to examine the possibility of using marmosets as a human oral disease model. The present investigation was designed to reveal the major bacteria in the oral cavity of marmosets and examine the similarity with those in the human oral cavity

The authors compared the saliva of 8 healthy marmosets (age range 10-18 years) with 8 healthy humans (age range 37-61 years) and performed a 16S rRNA gene sequencing.

They found Firmicutes, Bacteroides, Proteobacteria, and Actinobacteria as the major phylotypes in human saliva and Proteobacteria, Bacteroides, Fusobacteria and Firmicutes in marmoset saliva. 

Our study has demonstrated important similarities between oral microbes in marmosets and humans, particularly in relation to microbiome phyla, and revealed that oral microbes in marmosets exhibit higher diversity with less individual variations than human oral microbes.

They concluded that marmoset could be used as a model in studies of age-related oral diseases.

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Carmen Martín